Detection of donor-specific antibodies using HLA-coated microspheres: another tool for kidney transplant risk stratification**Portions of this study were delivered as an oral presentation at the American Transplant Congress, Seattle, WA, 20–25 May 2005.

Abstract

The detection of DSAs by Luminex microspheres was associated with significantly higher rates of graft dysfunction and immunological events. Conversely, the presence of antibodies but no DSA by Luminex was associated with excellent outcomes. In patients with negative AHG-CDC crossmatches, the occurrence of low-level DSA by Luminex could assist in identifying patients that require more aggressive immune monitoring or immunosuppressive strategies.