Concise Syntheses of Meridianins by Carbonylative Alkynylation and a Four‐Component Pyrimidine Synthesis

Abstract

In one go: (Hetero)aryl iodides, alkynes, carbon monoxide, and amidines can be assembled in a consecutive four-component reaction to give pyrimidines by a sequence of carbonylative alkynylation and cyclocondensation. Carbonylative alkynylation also is the key step in the two-step syntheses of meridianins and meridianin derivatives.