Enantioselective Relay Catalytic Cascade Intramolecular Hydrosiloxylation and Mukaiyama Aldol Reaction

Abstract

Cascading chemistry! The first practical relay catalytic cascade intramolecular hydrosiloxylation of arylacetylene and asymmetric Mukaiyama aldol reaction has been established to give synthetically useful products in high yields and with excellent ee (see scheme).