Genomic Differences Between Pure Ductal Carcinoma <i>In Situ</i> of the Breast and that Associated with Invasive Disease: a Calibrated aCGH Study

Abstract

Our findings suggest that DCIS and IDC are associated with specific genomic events. DCIS associated with IDC is genomically similar to the invasive component and therefore may represent either a clone with high invasive potential or invasive cancer spreading through the ducts. Specifically, gain on 17q22-24.2 is a candidate region for further testing as a predictor of invasion when detected in DCIS and predictor of nodal metastasis when detected in DCIS or IDC.