A prospective and comparative cohort study on efficacy and drug resistance during long‐term lamivudine treatment for various stages of chronic hepatitis B and cirrhosis

Abstract

Lamivudine was effective in reducing HBV-DNA and improving hepatic reserve at all stages and was most beneficial and significant for decompensated cirrhosis. Meanwhile, close monitoring of viral load and immediate rescue treatment for lamivudine resistance is necessary to prevent hepatic failure in decompensated cirrhosis.