Noninvasive Imaging of Dendrimer‐Type N‐Glycan Clusters: In Vivo Dynamics Dependence on Oligosaccharide Structure

Abstract

Body image: Self-activating Huisgen 1,3-dipolar cycloaddition and 6π azaelectrocyclization of lysine-based dendrimers (see picture) enable the in vivo dynamics and organ-specific accumulation of N-glycans to be visualized. The sugar structure and glycosyl bond linkages of N-glycans control the whole-body trafficking of the clusters in nude mice and a cancer model.