<i>MicroRNA-218</i>Inhibits Cell Migration and Invasion in Renal Cell Carcinoma through Targeting<i>Caveolin-2</i>Involved in Focal Adhesion Pathway

Abstract

Loss of tumor suppressive miR-218 enhances cancer cell migration and invasion through dysregulation of the focal adhesion pathway, especially CAV2 as an oncogenic function in renal cell carcinoma. Tumor suppressive microRNA mediated cancer pathways and responsible genes provide new insights into the potential mechanisms of renal cell carcinoma oncogenesis and metastasis.