An Increased Risk of Second Malignant Neoplasms After Rhabdomyosarcoma: Population‐Based Evidence for a Cancer Predisposition Syndrome?

Abstract

Children with rhabdomyosarcoma are at high risk of developing SMN. This risk is higher for a subgroup of young children with pleomorphic and embryonal histologies, and is independent of the use of radiation. This suggests that a subgroup of children with pleomorphic and embryonal rhabdomyosarcoma may have a constitutional cancer predisposition.