The role of the dorsomedial striatum in instrumental conditioning

TLDR

Instrumental conditioning in rats involves learning action–outcome relationships. The study examined the role of the dorsomedial striatum in action–outcome learning using lesions and reversible inactivation. Three experiments trained rats to press two levers for distinct outcomes and then tested them with established assays for action–outcome learning. Lesions or inactivation of the posterior dorsomedial striatum, but not the anterior region, abolished rats’ sensitivity to outcome devaluation and contingency degradation, indicating that the posterior DMS is essential for acquiring and expressing action–outcome associations.

Abstract

Abstract Considerable evidence suggests that, in instrumental conditioning, rats learn the relationship between actions and their specific consequences or outcomes. The present study examined the role of the dorsomedial striatum (DMS) in this type of learning after excitotoxic lesions and reversible, muscimol‐induced inactivation. In three experiments, rats were first trained to press two levers for distinct outcomes, and then tested after training using a variety of behavioural assays that have been established to detect action‐outcome learning. In Experiment 1, pre‐training lesions of the posterior DMS abolished the sensitivity of rats' instrumental performance to both outcome devaluation and contingency degradation when tested in extinction, whereas lesions of the anterior DMS had no effect. In Experiment 2, both pre‐training and post‐training lesions of the posterior DMS were equally effective in reducing the sensitivity of performance both to devaluation and degradation treatments. In Experiment 3, the infusion of muscimol into the posterior DMS selectively abolished sensitivity of performance to devaluation and contingency degradation without impairing the ability of rats to discriminate either the instrumental actions performed or the identity of the earned outcomes. Taken together, these results suggest that the posterior region of the DMS is a crucial neural substrate for the acquisition and expression of action–outcome associations in instrumental conditioning.