The First Solid-Phase Synthesis of a Peptide-Tethered Platinum(II) Complex

Abstract

Assembly of an immobilized tripeptide, platination, and subsequent deprotection and release from the solid support are the key steps in the solid-phase peptide synthesis of the peptide–platinum(II) complex 1. This new methodology should be applicable for the preparation of a library of platinum antitumor compounds by a combinatorial synthesis approach.