Increased Natural Killer Cell Cytotoxicity and NKp30 Expression Protects Against Hepatitis C Virus Infection in High-Risk Individuals and Inhibits Replication In Vitro

Abstract

CD56(pos) populations in EUs are enriched for effector NKs displaying enhanced IL-2-induced cytolytic activity and higher levels of the natural cytotoxicity receptor NKp30-activating receptor. In addition, NKp30(high) cells are more effective in preventing infection of Huh-7.5 cells than their NKp30(low/neg) counterparts. These data support the hypothesis that NK cells contribute to anti-HCV defense in vivo in the earliest stages of infection, providing innate protection from HCV acquisition.