Colorectal Cancer With Mutation in <i>BRAF</i>, <i>KRAS</i>, and Wild-Type With Respect to Both Oncogenes Showing Different Patterns of DNA Methylation

Abstract

In CRC, the methylation status of multiple promoters can be predicted through knowledge of BRAF and, to a lesser extent, KRAS activating mutations, indicating that these mutations are closely associated with different patterns of DNA hypermethylation. These changes may be important events in colorectal tumorigenesis.