Implementation of isoniazid preventive therapy in an <scp>HIV</scp> clinic in Cambodia: high rates of discontinuation when combined with antiretroviral therapy

Abstract

Although overall completion rates were acceptable, IPT discontinuation due to drug toxicity was common in patients subsequently initiating ART. Future studies should evaluate whether this relates to IPT, ARVs or both, and whether the increased toxicity would justify delaying IPT initiation until stabilisation on ART.