Age-related changes in the expression of NMDA, serotonin, and GAD in the central auditory system of the rat

Abstract

The total number of neuronal cell bodies of the CAS did not differ significantly at each level between young and aged rats (p > 0.05). Serotonin expression was increased with age in the IC and MGB, but decreased in the CN, SON, and AC (p < 0.05). NMDAR was significantly higher in the CN, MGB, and AC of aged compared with young rats, but was significantly decreased over time in the SOC and IC (p < 0.05). GAD67 was increased with age in the MGB and AC and decreased in the CN and SON (p < 0.05), but was not changed in the IC.