Functional Neuroanatomy of Visuospatial Working Memory in Fragile X Syndrome: Relation to Behavioral and Molecular Measures

Abstract

Subjects with fragile X syndrome are unable to modulate activation in the prefrontal and parietal cortex in response to an increasing working memory load, and these deficits are related to a lower level of FMRP expression in fragile X syndrome subjects than in normal comparison subjects. The observed correlations between biological markers and brain activation provide new evidence for links between gene expression and cognition.