Publication | Closed Access
A strategic approach to the synthesis of functionalized spirooxindole pyrrolidine derivatives: in vitro antibacterial, antifungal, antimalarial and antitubercular studies
122
Citations
56
References
2014
Year
Antitubercular StudiesVitro AntibacterialOrganic ChemistryPharmaceutical ChemistryMedicinal ChemistryStereoselective SynthesisDerivativesStrategic ApproachBiochemistryAntifungal AgentsDiversity-oriented SynthesisDft CalculationsAntimicrobial CompoundPharmacologyBiomolecular EngineeringAntifungal AgentNatural SciencesCycloaddition ReactionMedicineSpirooxindole Pyrrolidine DerivativesDrug Discovery
A series of spirooxindole pyrrolidine derivatives has been synthesized and evaluated for their<italic>in vitro</italic>biological activities. The observed regio- and stereoselectivity of the cycloaddition reaction has been rationalized using DFT calculations.
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