Iridium(III)‐Catalyzed CH Amidation of Arylphosphoryls Leading to a <i>P</i>‐Stereogenic Center

Abstract

Direct CH amidation of arylphosphoryl compounds has been developed by using an Ir(III) catalyst system under mild conditions. A wide range of substrates could be employed with high functional-group tolerance. This procedure was successfully applied for the first time to the asymmetric reaction giving rise to a P-chirogenic center with a high diastereomeric ratio of up to 19:1 (90 % de).