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Accumulation of p53 Tumor Suppressor Gene Protein: An Independent Marker of Prognosis in Breast Cancers

DOI

733

Citations

0

References

1992

Year

Ann D. Thor, Dan H. Moore, S M Edgerton, Ernest S. Kawasaki, Ellen Reihsaus, Henry T. Lynch, Joseph Marcus, L. Schwartz, L.-C. Chen, Brian H. Mayall,
JNCI Journal of the National Cancer Institute

Abstract

Immunohistochemically detected p53 protein accumulation was an independent marker of shortened survival and was seen more often in familial than in sporadic carcinomas. Our findings also suggest a correlation between p53 protein accumulation and p53 gene mutation.