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Isotachophoresis quantitation of subtractions of multiple sclerosis intra‐blood‐brain barrier IgG synthesis modulated by ACTH and/or steroids
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1982
Year
Neurological DisorderImmunologyImmune RegulationNeurological ProgressActh And/or SteroidsSocial SciencesNeuroinflammationTranslational MedicineNeurobiology Of DiseaseNeurologyNeuropathologyNeuroimmunologyNeurological FunctionIgg Synthesis RateAutoimmune DiseaseIsotachophoresis QuantitationAutoimmunityBrain-immune InteractionImmune FunctionCerebral Blood FlowMost IggNeurophysiologyNeuroscienceMultiple SclerosisMedicine
We combined the IgG is otachophoresis (ITP) method and a formula to quantitate IgG synthesis rate inside the blood-brain barrier (intra-BBB) in multiple sclerosis (MS) patients. In MS, most IgG synthesized was cathodic, but synthesis occurred in both anodic and cathodic regions. In addition, ACTH and/or steroids were found to reduce cathodic IgG synthesis more than anodic.