Bioavailability enhancement of ondansetron after nasal administration of <i>Caesalpinia pulcherrima-</i>based microspheres

Abstract

CPG-based mucoadhesive microspheres can successfully deliver ondansetron intranasally, sustain its effect, avoid first pass effect, an alternative route of administration to injection and thus enhance systemic bioavailability of ondansetron hydrochloride.