Autoantibodies against Folate Receptors in Women with a Pregnancy Complicated by a Neural-Tube Defect

Abstract

Serum from women with a pregnancy complicated by a neural-tube defect contains autoantibodies that bind to folate receptors and can block the cellular uptake of folate. Further study is warranted to assess whether the observed association between maternal autoantibodies against folate receptors and neural-tube defects reflects a causal relation.