Palladium‐Catalyzed Cross‐Coupling of Internal Alkenes with Terminal Alkenes to Functionalized 1,3‐Butadienes Using CH Bond Activation: Efficient Synthesis of Bicyclic Pyridones

Abstract

A highly regioselective direct cross-coupling of internal alkenes of α-oxoketene dithioacetals with terminal alkenes has been successfully realized by palladium-catalyzed CH bond activation, affording functionalized 1,3-butadienes. Condensation of the resultant 1,3-butadienes by diamines efficiently produced potentially bioactive bicyclic pyridone derivatives (see scheme). Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.