An Alkoxide‐Directed Intermolecular [2+2+1] Annulation: A Three‐Component Coupling Reaction for the Synthesis of Tetrasubstituted α,β‐Unsaturated γ‐Lactams

Abstract

In full control: A regio- and stereoselective cross-coupling reaction between internal alkynes and imines that provides selective access to allylic amines and γ-lactams has been developed (see scheme). This intermolecular [2+2+1] process could be described as an alkoxide-directed aza-Pauson–Khand-like annulation. The alkyne can tolerate a wide range of substituents R3. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z605060_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.