PAP and NT5E Inhibit Nociceptive Neurotransmission by Rapidly Hydrolyzing Nucleotides to Adenosine

Abstract

Collectively, our experiments indicate that PAP and NT5E are the main ectonucleotidases that generate adenosine in nociceptive circuits and indicate these enzymes transform pulsatile or sustained nucleotide release into an inhibitory adenosinergic signal.