<i>KCNE5</i> ( <i>KCNE1L</i> ) Variants Are Novel Modulators of Brugada Syndrome and Idiopathic Ventricular Fibrillation

Abstract

KCNE5 modulates I(to), and its novel variants appeared to cause IVF, especially BrS, in male patients through gain-of-function effects on I(to). Screening for KCNE5 variants is relevant for BrS or IVF.