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Enantioselective Mukaiyama–Michael Reaction of Silyl Enol Ethers to 2‐Enoylpyridine <i>N</i>‐Oxides Catalyzed by Copper‐ Bis(oxazoline) Complex
20
Citations
60
References
2013
Year
Chemical EngineeringSimple BisEngineeringN ‐OxidesCatalytic SynthesisOrganic ChemistrySilyl Enol EthersOrganometallic CatalysisCatalysisChemistryAsymmetric CatalysisSynthetic ChemistryEnantioselective SynthesisEnantioselective Mukaiyama–michael ReactionCopper‐ Bis
Abstract A catalytic enantioselective Mukaiyama–Michael reaction of 2‐enoylpyridine N ‐oxides has been developed using a simple bis(oxazoline)‐copper complex. A variety of silyl enol ethers undergo smooth Michael addition with 2‐enoylpyridine N ‐oxides to furnish the corresponding Michael adducts in high yields with high enantioselectivities (up to 97% ee ).
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