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Structure and absolute configuration of emestrin, a new macrocyclic epidithiodioxopiperazine from Emericell striata
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1985
Year
Drug TargetBioorganic ChemistryNew Macrocyclic EpidithiodioxopiperazineMedicinal FungiChemical BiologyEnzymatic ModificationEmericell StriataMedicinal ChemistryMycelial Acetone ExtractAbsolute ConfigurationBiochemistryNatural Product SynthesisPharmacologyMethanol SolvateNatural SciencesRational Drug DesignEmericella StriataMedicineDrug DiscoveryDrug Analysis
The structure elucidation of emestrin (1), a macrocyclic epidithioxopiperazine derivative isolated from the mycelial acetone extract of Emericella striata, is reported, based on its 1H and 13C n.m.r. spectra and an X-ray crystallographic study of its methanol solvate; its absolute configuration was established by its c.d. spectrum.