Effects of Intraduodenal Infusion of L-Tryptophan on ad Libitum Eating, Antropyloroduodenal Motility, Glycemia, Insulinemia, and Gut Peptide Secretion in Healthy Men

Abstract

Low caloric intraduodenal loads of L-Trp affect gut motor and hormonal function and markedly reduce energy intake. A strong inverse correlation between energy intake and plasma L-Trp suggests that, beyond gut mechanisms, direct effects of circulating L-Trp mediate its eating-inhibitory effect.