Proximity of brain infarcts to regions of endogenous neurogenesis and involvement of striatum in ischaemic stroke

Abstract

Many stroke patients have infarcts located close to the SVZ, providing some supportive evidence that optimized endogenous neurogenesis may have therapeutic potential. However, predominantly striatal infarcts are rare and tend to give mild neurological deficits, indicating that striatum should not be the primary target for neuronal replacement efforts in humans.