Iron Overload Decreases Ca <sub>V</sub> 1.3-Dependent L-Type Ca <sup>2+</sup> Currents Leading to Bradycardia, Altered Electrical Conduction, and Atrial Fibrillation - Concepedia

Concepedia

Publication | Open Access

Iron Overload Decreases Ca <sub>V</sub> 1.3-Dependent L-Type Ca <sup>2+</sup> Currents Leading to Bradycardia, Altered Electrical Conduction, and Atrial Fibrillation

DOI Full Paper Access

84

Citations

35

References

2011

Year

Robert A. Rose, Michael Sellan, Jeremy A. Simpson, Farzad Izaddoustdar, Carlo Cifelli, Brian K. Panama, Mark Davis, Dongling Zhao, Moniba Markhani, Geoffrey G. Murphy,

Circulation Arrhythmia and Electrophysiology

Abstract

Our results demonstrate that CIO selectively reduces Ca(V)1.3-mediated I(Ca,L), leading to bradycardia, slowing of electrical conduction, and atrial fibrillation as seen in patients with iron overload.

References

	Year	Citations

Page 1