Crystal Structure and Mechanism of a DNA (6‐4) Photolyase

Abstract

Before and after: Crystal structures of the DNA (6-4) photolyase from D. melanogaster—one structure in complex with DNA containing a (6-4) lesion (see picture) and one in which the lesion has been repaired—provide new insight into lesion recognition and repair. The proposed mechanism for light-induced, electron-transfer-based repair of the (6-4) lesion does not proceed via an oxetane intermediate. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.