Highly efficient Lewis acid-catalysed Pictet–Spengler reactions discovered by parallel screeningElectronic supplementary information (ESI) available: full experimental procedures. See http://www.rsc.org/suppdata/cc/b2/b212063a/

Abstract

High yielding Lewis acid-catalysed one-pot Pictet-Spengler reactions of tryptophan methyl ester and tryptamine with aliphatic and aromatic aldehydes were achieved in short reaction times with the aid of microwave irradiation.