Concepedia

Publication | Closed Access

Pharmacodynamics of active site‐inhibited factor VIIa in endotoxin‐induced coagulation in humans

DOI

68

Citations

0

References

2002

Year

Bernd Jilma, Claudia Marsik, Florian Mayr, Monika Graninger, Fletcher B. Taylor, Mette C. Ribel, Elisabeth Erhardtsen, Sylvia Handler, Hans Georg Eichler
Clinical Pharmacology & Therapeutics

Abstract

In summary, ASIS effectively and selectively attenuates tissue factor-induced thrombin generation. Because ASIS was well tolerated, this study provides seminal data to further characterize its anticoagulant and putative anti-inflammatory effects in critically ill patients.