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Induction of the SOS response by new 4-quinolones
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1987
Year
BacteriologyPharmaceutical ChemistryGalactose OperonsDrug ResistanceSos ResponseAntimicrobial ResistanceHealth SciencesBiochemistryVirulence FactorMolecular MicrobiologyEscherichia Coli K12Pharmacology:Lacz Gene FusionClinical MicrobiologyAntimicrobial SusceptibilityAntibioticsPathogenesisMicrobiologyMedicineDrug Discovery
The 4-quinolones ciprofloxacin, difloxacin, enoxacin, norfloxacin, ofloxacin, and nalidixic acid were found to induce the SOS response in qualitative and quantitative tests on Escherichia coli K12 containing the sfiA::lacZ gene fusion. Maximum induction of the SOS-response was observed with the quinolone concentrations that produced the most killing. There was also a modest increase in the rate of mutation in the lactose and galactose operons in a GalE- background, provided there was a functioning SOS system.