Histone Deacetylase Inhibitors Induce a Very Broad, Pleiotropic Anticancer Drug Resistance Phenotype in Acute Myeloid Leukemia Cells by Modulation of Multiple ABC Transporter Genes - Concepedia

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Histone Deacetylase Inhibitors Induce a Very Broad, Pleiotropic Anticancer Drug Resistance Phenotype in Acute Myeloid Leukemia Cells by Modulation of Multiple ABC Transporter Genes

107

Citations

45

References

2009

Year

Stefanie Hauswald, Jesús Duque‐Afonso, Michaela Wagner, Florian M. Schertl, Michael Lübbert, Christian Peschel, Ulrich Keller, Thomas Licht

Clinical Cancer Research

Abstract

Exposure of AML cells to HDACi induces a drug resistance phenotype broader than the "classic multidrug resistance," which might negatively affect treatment effectiveness.

References

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