Dyslipidaemia in type II diabetic mice does not aggravate contractile impairment but increases ventricular stiffness

Abstract

Type II diabetes in mice leads to impaired contractility and relaxation due to disturbed Ca(2+) reuptake in the SR, but only when dyslipidaemia and hypertension are superimposed does vascular-ventricular stiffening increase and left ventricular myocardial fibrosis develop.