Strong interaction between the effects of alcohol consumption and smoking on oesophageal squamous cell carcinoma among individuals with <i>ADH1B</i> and/or <i>ALDH2</i> risk alleles

Abstract

Analysis of ADH1B and ALDH2 variants is valuable for secondary prevention of OSCC in high-risk patients who smoke and drink alcohol. In this study, SNP genotyping demonstrated that the ADH1B and/or ALDH2 risk alleles had an interaction with smoking and, especially, alcohol consumption. These findings, if replicated in other groups, could demonstrate new pathophysiological pathways for the development of OSCC.