In Vivo Selection of<i>Plasmodium falciparum</i>Parasites Carrying the Chloroquine-Susceptible<i>pfcrt</i>K76 Allele after Treatment with Artemether-Lumefantrine in Africa

Abstract

Our findings suggest that the pfcrt K76T mutation is a drug-specific contributor to enhanced P. falciparum susceptibility to lumefantrine in vivo and in vitro, and they highlight the benefit of using AL in areas affected by chloroquine-resistant P. falciparum malaria.