Technetium-99m-tetrofosmin as a new radiopharmaceutical for myocardial perfusion imaging.

TLDR

A freeze‑dried kit containing the cationic complex [99mTc(tetrofosmin)2O2]+, synthesized with the ether‑functionalized diphosphine ligand, enables high‑purity myocardial perfusion imaging agents up to 8 h after reconstitution. X‑ray crystallography of the 99Tc analog confirms the complex structure, and the tetrofosmin species shows markedly faster clearance from blood and liver than other 99mTc alkyl‑phosphine complexes while maintaining high radiochemical purity.

Abstract

A new cationic complex, [99mTc(tetrofosmin)2O2]+, where tetrofosmin is the ether functionalized diphosphine ligand 1,2-bis[bis(2-ethoxyethyl)phosphino]ethane, has been synthesized and evaluated for potential use in myocardial perfusion imaging. The structure of the complex has been determined by x-ray crystallography of the 99Tc analog. In comparison with previously reported 99mTc complexes of alkyl-phosphines, the tetrofosmin species shows substantially increased clearance from nontarget tissue, especially blood and liver. A freeze-dried kit formulation has been developed. The kit provides a product of high radiochemical purity up to 8 hr after reconstitution at room temperature.