Regulation of swelling-activated Cl- current by angiotensin II signalling and NADPH oxidase in rabbit ventricle

Abstract

Activation of I Cl,swell by osmotic swelling is controlled by the AngII-ROS cascade, the same pathway previously implicated in I Cl,swell activation by integrin stretch. This in part explains why I Cl,swell is persistently activated in several models of cardiac disease.