The Impact of Image Reconstruction Bias on PET/CT ⁹⁰Y Dosimetry After Radioembolization

Abstract

The low signal-to-noise ratio caused by low positron emission rates and high bremsstrahlung photon production resulted in a positive bias on (90)Y PET images reconstructed with conventional iterative algorithms. However, quantitative accuracy was good at high activity concentrations, such as those found in tumor volumes, allowing for adequate tumor (90)Y PET/CT dosimetry after radioembolization.