Human recombinant erythropoietin inhibits interleukin-1 -stimulated nitric oxide and cyclic guanosine monophosphate production in cultured rat vascular smooth-muscle cells

Eiji Kusano, Takayuki Akimoto, Makoto Inoue, Y. Masunaga, T. Umino, Shuichi Ono, Yukio Ando, Sumiko Homma, Shigeaki Muto, Norio Komatsu,

Nephrology Dialysis Transplantation · 1999 · 31 citations · 0 references

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Abstract

It is suggested that a pharmacological dose of rHuEpo inhibits IL-1beta-induced NO and cGMP production as well as iNOS mRNA expression, presumably via the Epo receptor.