Application of Bone Marrow-Derived Mesenchymal Stem Cells in a Rotator Cuff Repair Model

Abstract

A biologic solution to the problem of tendon-to-bone healing in the rotator cuff remains elusive. The repair site may lack the cellular and/or molecular signals necessary to induce appropriate differentiation of transplanted cells. Further studies are needed to determine if cell-based strategies need to be combined with growth and differentiation factors to be effective.