Chiral Scandium‐Catalysed Enantioselective Ring‐Opening of <i>meso</i>‐Epoxides with N‐Heterocycle, Alcohol and Thiol Derivatives in Water

Abstract

Abstract In the presence of catalytic amounts of Sc(OSO 3 C 12 H 25 ) 3 and a chiral bipyridine ligand, asymmetric ring‐opening of meso ‐epoxides with aromatic N‐heterocycles, an alcohol and thiols proceeded smoothly to afford the corresponding products in moderate to good yields (34–85 %) with high to excellent enantioselectivities (74–96 % ee ). Water was used as the sole and essential solvent in these important enantioselective transformations.