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Total synthesis and structural elucidation of natural products: (–)-Delactonmycin, (+)-plumerinine, and (–)-parvistemoamide
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2005
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EngineeringOrganic ChemistryPharmaceutical ChemistryMedicinal ChemistryNatural ProductsRelative ConfigurationInhibitory ActivityBiochemistryStructural ElucidationTotal SynthesisPharmacologyAntiviral CompoundNatural Product SynthesisBiomolecular EngineeringNatural SciencesRational Drug DesignHiv-1 Rev ProteinSynthetic ChemistryDrug Discovery
Abstract Synthetic studies that established the relative configuration of (–)-delactonmycin, a polyketide with inhibitory activity against HIV-1 Rev protein, and our efforts toward the structural elucidation of the alkaloids (+)-plumerinine, isolated from P. rubra , and (–)-parvistemoamide, isolated from S. parviflora , are discussed.