Additive renoprotective effect of candesartan and tetrahydrobiopterin in rats after 5/6 nephrectomy

Abstract

This study shows that in subnephrectomized rats, addition of BH4 to a treatment with candesartan had an additive renoprotective effect. The mechanism of such action may include a better control of BP associated with a blockade of actions of angiotensin II (Ag II), an improvement in nitric oxide synthesis and a balanced redox.