Concepedia

Pentameric concatenated (α4)<sub>2</sub>(β2)<sub>3</sub> and (α4)<sub>3</sub>(β2)<sub>2</sub> nicotinic acetylcholine receptors: subunit arrangement determines functional expression

A‐L Carbone, Maria Moroni, PJ Groot-Kormelink, Isabel Bermúdez

British Journal of Pharmacology · 2009 · 132 citations · 40 references

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Abstract

We concluded that the alpha4beta2 nicotinic ACh receptors produced with beta2_alpha4_beta2_alpha4_beta2 or beta2_alpha4_beta2_alpha4_alpha4 pentameric constructs are valid models of non-linked (alpha4)(2)(beta2)(3) and (alpha4)(3)(beta2)(2) receptors respectively.

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