Mutations in Exon 11 of c-Kit Occur Preferentially in Malignant versus Benign Gastrointestinal Stromal Tumors and Do Not Occur in Leiomyomas or Leiomyosarcomas

Gain-of-Function Mutations of c- <i>kit</i> in Human Gastrointestinal Stromal Tumors

Seiichi Hirota, Koji Isozaki, Y Moriyama et al. · Science · 1998 · 4.5K citations

Medicine, Genetics, Oncology +17

Gastrointestinal pacemaker cell tumor (GIPACT): gastrointestinal stromal tumors show phenotypic characteristics of the interstitial cells of Cajal.

Lars Gunnar Kindblom, Helen Remotti, Frank Aldenborg et al. · PubMed · 1998 · 1.7K citations

Medicine, Cell Biology, Oncology +9

Human proto‐oncogene c‐kit: a new cell surface receptor tyrosine kinase for an unidentified ligand.

Yosef Yarden, Wun-Jing Kuang, Teresa L. Yang‐Feng et al. · The EMBO Journal · 1987 · 1.6K citations · Full text

Life Sciences, Molecular Biology, Oncology +13

Stem cell factor is encoded at the SI locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor

Krisztina M. Zsebo, David A. Williams, E N Geissler et al. · Cell · 1990 · 1.4K citations

Life Sciences, Cell Biology, Genetics +14

Characteristics of the Cholecystokinin-Induced Depolarization of Pacemaking Activity in Cultured Interstitial Cells of Cajal from Murine Small Intestine

Jae Hwa Lee, Sung-Young Kim, Young Kyu Kwon et al. · Cellular Physiology and Biochemistry · 2013 · 1.4K citations · Full text

Life Sciences, Pharmacology, Physiology +17