A Robust Electronic Switch Made of Immobilized Duplex/Quadruplex DNA

Abstract

Flicking a switch: A robust DNA nanoswitch has been designed by using a contractile DNA construct (G-quadruplex) as the switch medium and ferrocene (Fc) as a redox-active indicator (see picture). The switch was electrochemically tested and can be turned “on” or “off” repeatedly by the addition or removal, respectively, of the effector (K+ ions). The reversibility and repeatability of the DNA switch are directly monitored by electrochemical measurements.