Antimicrobial Agents and Chemotherapy · 2005 · 289 citations · 10 references
Life SciencesMicrobiologyMolecular GeneticsAntimicrobial ResistanceMedical MicrobiologyMicrobial GeneticsAntibacterial ResistanceAntibiotic ResistancePlasmid BiologyPlasmid GeneticsPlasmid-mediated ResistanceResistance GenesAntibiotic Resistance PlasmidsEscherichia ColiPlasmid-borne Antibiotic ResistancePlasmid-borne ResistancePlasmid-mediated Resistance TransferQuinolone Resistance GenesQuinolone Resistance PlasmidsResistance Plasmid Transfer
A novel gene for quinolone resistance was cloned from a transferable plasmid carried by a clinical isolate of Shigella flexneri 2b that was resistant to fluoroquinolones. The plasmid conferred low-level resistance to quinolones on Escherichia coli HB101. The protein encoded by the gene showed 59% amino acid identity with Qnr.
10